Key result
Single-dose caffeine increases pulse wave velocity within 60 minutes in healthy men.
Why the study?
Studies on the cardiovascular effects of caffeine have often produced contradictory results, particularly regarding arterial stiffness and pulse wave reflections.
Does a single oral dose of caffeine increase arterial stiffness and blood pressure in healthy male subjects?
RCT (n=36)
Double-blind
Parallel
Does a single oral dose of caffeine increase arterial stiffness and blood pressure in healthy male subjects?
p-value: p=<0.001
A single oral dose of caffeine acutely increases blood pressure and arterial stiffness in healthy men.
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Caffeine may confound PWV assessments; confirms acute stiffening effect on arteries in healthy men.
Pilli et al. (2012) conducted an RCT in Healthy (n=36). Caffeine vs. Placebo was evaluated on Pulse wave velocity (p=<0.001). A single oral dose of caffeine (250 mg or 500 mg) significantly increased pulse wave velocity at 30 minutes (P<0.05) and 60 minutes (P<0.001) in healthy male subjects.
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