Key result
Caffeinated and decaffeinated coffee consumption induced a more pronounced increase in arterial stiffness (PWV difference 0.39 m/s, p<.05) in non-habitual compared to habitual consumers.
Why the study?
Does coffee, decaffeinated coffee, or caffeine alone acutely increase arterial stiffness in healthy individuals?
RCT (n=24)
Does coffee, decaffeinated coffee, or caffeine alone acutely increase arterial stiffness in healthy individuals?
Mean Difference: 0.39
p-value: p=<.05
Both caffeinated and decaffeinated coffee acutely increase arterial stiffness more potently in non-habitual than habitual consumers, whereas caffeine alone induces comparable changes regardless of habituation.
Suggests greater acute stiffness effects in non-habitual coffee drinkers; hypothesis-generating for habituation and vascular tolerance.
The acute effect of coffee on arterial stiffness and its dependence on habitual consumption was studied in 24 volunteers on four separate occasions during which subjects received: (a) coffee espresso, (b) decaffeinated coffee espresso, (c) caffeine alone and (d) placebo (hot water). The increase in carotid femoral pulse wave velocity (PWV), augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform after coffee consumption was more pronounced in non-habitual (n = 13) compared to habitual drinkers (n = 11), (differences of maximal changes between groups in PWV, AIx, AP responses by 0.39 m/s, 4.5% and 1.9 mmHg, respectively, for coffee; and by 0.34 m/s, 5.3% and 2.1 mmHg, respectively, for decaffeinated coffee; all p < .05). Caffeine increased PWV, as well as AIx and AP but differences in responses between the two groups were not significant. Both caffeinated and decaffeinated coffee consumption is associated with a more potent effect on arterial stiffness in non-habitual than habitual coffee consumers, whereas caffeine induces comparable changes in both groups.
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Ioakeimidis et al. (2018) conducted an RCT in Healthy individuals (n=24). Coffee espresso, decaffeinated coffee espresso, and caffeine vs. Placebo (hot water) was evaluated on carotid femoral pulse wave velocity (PWV), augmentation index (AIx) and augmented pressure (AP) (MD 0.39, p=<.05). Caffeinated and decaffeinated coffee consumption induced a more pronounced increase in arterial stiffness (PWV difference 0.39 m/s, p<.05) in non-habitual compared to habitual consumers.
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