Key result
Caffeinated coffee acutely increased peripheral arterial stiffness parameters, including brachial systolic blood pressure by up to 3.9 mmHg (p<0.05), without changing pulse wave velocity.
Why the study?
Does acute consumption of caffeinated coffee increase arterial stiffness compared to decaffeinated coffee in healthy subjects?
RCT (n=32)
Blind
Random order
Does acute consumption of caffeinated coffee increase arterial stiffness compared to decaffeinated coffee in healthy subjects?
p-value: p=< 0.05
Acute consumption of caffeinated coffee slightly increases peripheral arterial stiffness and vascular tone in distal arteries without changing central stiffness (pulse wave velocity).
Acute caffeinated coffee raises peripheral BP and stiffness in healthy adults; extends prior contradictory data on vascular effects.
Introduction: Previous studies show contradictory results related to the vascular effects of coffee; they suggest that caffeine increases arterial stiffness and negatively impacts vascular health, the aim of this study is to evaluate the acute coffee effects on the vascular stiffness. Methods and materials: We carried out a controlled, blind, cohort study in healthy subjects. The acute effect of coffee (caffeinated vs. decaffeinated) was evaluated on arterial stiffness parameters, using a oscillometric method known as Arteriograph® (TensioMed-Budapest-Hungary, Ltd.). Each subject received 14 gr. of caffeinated excelso-coffee (caffeine-151.2 mg) and decaffeinated excelso-coffee (caffeine-3.92 mg), two weeks apart in a random order. The parameters were obtained under stable baseline conditions before drinking the coffee, 30 and 60 min later. Results: Thirty-two subjects were included, with an age of 46.2 ± 10.4 years, sixteen men. Consumption of caffeinated-coffee at 30 and 60 min increased statistically significant (p < 0.05) brachial-systolic-blood-pressure in 3.9 mmHg and 3.8 mmHg, brachial-diastolic-blood-pressure in 4.1 mmHg and 3.2 mmHg, mean-arterial-pressure in 4.0 mmHg and 3.3 mmHg, central-systolic-blood-pressure in 5.8 mmHg and 7.6 mmHg, brachial-AIX 9.9% and 12.3%, aortic-AIX 5.1% and 6.3%, decreased heart-rate by 4 beats/min and 5 beats/min respectively, and it not demonstrated that had an impact on the pulse wave velocity (p = 0.861). Decaffeinated-coffee increased the braquial-AIX (7.1–10.5%) and aortic-AIX (3.55–5.3%) and decreased the heart-rate (3–4 beats/min). Conclusions: This study suggests for the first time that drinking caffeinated coffee slightly increases peripheral arterial stiffness at the expense of increased vascular tone in distal arteries without changes in central stiffness. Further studies are needed to clarify whether these effects induced by coffee have an impact on the population health.
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Echeverri et al. (2017) conducted an RCT in Healthy subjects (n=32). Caffeinated coffee vs. Decaffeinated coffee (3.92 mg caffeine) was evaluated on Arterial stiffness parameters (including blood pressure, augmentation index, heart rate, and pulse wave velocity) (p=< 0.05). Caffeinated coffee acutely increased peripheral arterial stiffness parameters, including brachial systolic blood pressure by up to 3.9 mmHg (p<0.05), without changing pulse wave velocity.
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