Key result
Subsegmental pulmonary embolism accounted for 3.8% of all pulmonary embolisms and was associated with similar 3-month rates of mortality, VTE recurrence, and major bleeding compared to more proximal or no pulmonary embolism.
Why the study?
Subsegmental pulmonary embolism incidence has increased with imaging improvements, but treatment clinical equipoise persists, and existing studies have significant heterogeneity and lack adequately matched comparator groups.
Does the presence of subsegmental pulmonary embolism compared to other PE types or no PE affect 3-month mortality, VTE recurrence, and major bleeding in adults undergoing CTPA?
Population
Adult patients undergoing CTPA at 3 UK hospitals (14,300 CTPA reports, 2,055 PEs, 79 SSPEs)
Comparison
SSPE vs main, lobar, segmental, and no PE
Design
Multicentre observational propensity-matched study
Follow-up
3 months
Authors
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SSPE outcomes similar across comparator groups; leaves open optimal anticoagulation strategy pending randomized trials.
Observational (n=395)
Yes
Does the presence of subsegmental pulmonary embolism compared to other PE types or no PE affect 3-month mortality, VTE recurrence, and major bleeding in adults undergoing CTPA?
Subsegmental pulmonary embolism accounts for 3.8% of all PEs and has similar 3-month mortality, VTE recurrence, and major bleeding compared to other PE types or no PE, often presenting with alternative radiological findings that may explain symptoms.
Armitage et al. (2022) conducted an observational in Subsegmental pulmonary embolism (n=395). Subsegmental pulmonary embolism vs. More proximal pulmonary embolism or no pulmonary embolism was evaluated on 3-month mortality, VTE recurrence, and major bleeding. Subsegmental pulmonary embolism accounted for 3.8% of all pulmonary embolisms and was associated with similar 3-month rates of mortality, VTE recurrence, and major bleeding compared to more proximal or no pulmonary embolism.
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