Key result
Nonalcoholic hepatic steatosis in mildly obese individuals was associated with markedly lower plasma adiponectin concentrations compared to those without steatosis (5.6 vs 10.8 μg/ml; P<0.001).
Why the study?
Is nonalcoholic hepatic steatosis associated with decreased plasma adiponectin concentrations in healthy obese individuals?
Population
68 healthy, mildly obese individuals with a negative or negligible daily alcohol consumption
Comparison
Presence of nonalcoholic hepatic steatosis vs Absence of nonalcoholic hepatic steatosis (n=25)
Design
Cross-sectional
Authors
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May flag higher metabolic risk in mild obesity; hypothesis-generating and should not change practice.
Cross-Sectional (n=68)
Is nonalcoholic hepatic steatosis associated with decreased plasma adiponectin concentrations in healthy obese individuals?
Absolute Event Rate: 5.6% vs 10.8%
p-value: p=<0.001
Decreased plasma adiponectin concentrations are closely correlated with nonalcoholic hepatic steatosis in healthy obese individuals, independent of potential confounders.
Targher et al. (2004) conducted a cross-sectional in Obesity (n=68). Nonalcoholic hepatic steatosis vs. Without nonalcoholic hepatic steatosis was evaluated on Plasma adiponectin concentration (μg/ml) (p=<0.001). Nonalcoholic hepatic steatosis in mildly obese individuals was associated with markedly lower plasma adiponectin concentrations compared to those without steatosis (5.6 vs 10.8 μg/ml; P<0.001).
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