Key result
Endotoxin administration in newborn piglets reduced beat-to-beat heart rate variability by 2.2 ms (p<0.05) and decreased baroreflex sensitivity during fever.
Why the study?
Does a low dose of endotoxin impair autonomic nervous system function in newborn piglets?
Population
30 newborn piglets
Comparison
Low dose of endotoxin vs Baseline state
Design
Preclinical
Authors
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Endotoxin impairs autonomic function in newborn piglets; leaves open mechanistic links to SIDS risk in humans.
Does a low dose of endotoxin impair autonomic nervous system function in newborn piglets?
Mean Difference: -2.2
Absolute Event Rate: 4.8% vs 7%
p-value: p=<0.05
Endotoxin-induced fever alters autonomic tone and reduces autonomic responsiveness in newborn piglets, providing a potential physiological link to risk factors for sudden infant death syndrome.
Voss et al. (2004) studied Sudden infant death syndrome (SIDS) model (n=30). Endotoxin (Salmonella abortus equi) vs. Pre-endotoxin (external warming) was evaluated on Beat-to-beat heart rate variability (SDDeltaRR) (MD -2.2 ms, p=<0.05). Endotoxin administration in newborn piglets reduced beat-to-beat heart rate variability by 2.2 ms (p<0.05) and decreased baroreflex sensitivity during fever.
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