Key result
In a swine model with induced left bundle branch block, ECG changes accurately identified the occluded coronary artery during the first 5 minutes of ischemia, but after 3 hours only left anterior descending artery occlusion remained reliably recognizable.
Why the study?
Electrocardiographic diagnosis of acute myocardial ischemia is hampered in the presence of left bundle branch block.
Does left bundle branch block mask the ECG recognition of acute coronary artery occlusion of distinct location and duration in a pig model?
Does left bundle branch block mask the ECG recognition of acute coronary artery occlusion of distinct location and duration in a pig model?
In a pig model, LBBB does not mask the ECG recognition of the occluded coronary artery during the first 60 minutes of ischemia, and ST elevation in leads V7 to V9 is specific for LCX occlusion.
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Porcine LBBB model data on ischemia effects leave open human ECG diagnostic refinements; prospective clinical validation required.
Jorge et al. (2019) studied Acute myocardial ischemia with left bundle branch block (n=14). Acute coronary artery occlusion vs. Baseline was evaluated on Electrocardiographic changes (ST segment deviation and QRS morphology) identifying the occluded artery. In a swine model with induced left bundle branch block, ECG changes accurately identified the occluded coronary artery during the first 5 minutes of ischemia, but after 3 hours only left anterior descending artery occlusion remained reliably recognizable.
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