In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes*

February 12, 2010Critical Care MedicineOpen Access

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This study aims to assess the impact of endotoxin on clock gene expression in human peripheral blood leukocytes during different circadian phases.
Healthy volunteers received either endotoxin (2 ng/kg) or saline at 0900 or 2100 hrs.
Blood samples were collected pre- and post-infusion to analyze gene expression.
Clock gene expression was measured using quantitative real-time polymerase chain reaction.
Endotoxin caused a suppression of clock gene expression by 80% to 90% in leukocytes within 3 to 6 hours.
Per1 and Per2 gene expression reached their lowest levels between 13 and 17 hours post-infusion.
Cytokine levels peaked and returned to baseline within 6 hours, while clock gene expression remained suppressed for up to 17 hours.

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Clinical investigation examines how endotoxin affects clock gene expression in human leukocytes, suggesting implications for disease recovery.

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Haimovich et al. (2010) studied this question.

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