Key result
The ACTT and ECT assays demonstrated greater sensitivity to bivalirudin plasma concentrations (28.4 and 28.8 sec/µg/ml, respectively) compared to standard ACT assays (13.5-15.0 sec/µg/ml) during cardiac surgery.
Why the study?
Does the ACTT assay accurately correlate with bivalirudin plasma levels in patients undergoing on-pump cardiac surgery?
Population
10 sequential patients presenting for elective cardiac surgery (CABG) requiring cardiopulmonary bypass
Design
Case_series
Authors
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May support ACTT for bivalirudin monitoring in cardiac surgery; hypothesis-generating case report leaves validation open.
Observational (n=10)
No
Does the ACTT assay accurately correlate with bivalirudin plasma levels in patients undergoing on-pump cardiac surgery?
Absolute Event Rate: 28.4% vs 15%
The modified ACTT assay demonstrates high sensitivity to bivalirudin concentrations and may offer a simple method for monitoring bivalirudin during on-pump cardiac surgery.
Zucker et al. (2005) conducted an observational in Elective cardiac surgery requiring cardiopulmonary bypass (n=10). ACTT and ECT assays vs. Standard ACT assays (Celite, kaolin, ACT+) was evaluated on Sensitivity to bivalirudin concentration (change in clotting time per µg/mL). The ACTT and ECT assays demonstrated greater sensitivity to bivalirudin plasma concentrations (28.4 and 28.8 sec/µg/ml, respectively) compared to standard ACT assays (13.5-15.0 sec/µg/ml) during cardiac surgery.
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