Key result
A newly developed hybrid mock circulatory loop demonstrated a good representation of the human cardiovascular system and the capability of real-time variation of physiological conditions.
Population
In vitro hybrid mock circulatory loop (MCL) model for total artificial heart (TAH) performance evaluation
Design
Preclinical
Authors
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Hybrid MCL broadens TAH testing across conditions; leaves clinical translation open pending further validation.
The developed hybrid mock circulatory loop provides a valuable in vitro test platform for evaluating mechanical circulatory support devices and their control algorithms prior to animal experiments.
Cuenca‐Navalon et al. (2014) studied Total artificial heart testing. Hybrid mock circulatory loop (MCL) was evaluated on Representation of the human cardiovascular system and capability of real-time variation of physiological and pathological conditions. A newly developed hybrid mock circulatory loop demonstrated a good representation of the human cardiovascular system and the capability of real-time variation of physiological conditions.
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