Key result
A multiobjective hemodynamic control algorithm demonstrated more robust performance in an in vitro mock circulatory simulator compared with controllers relying on individual indices.
Population
In vitro mock circulatory simulator using a HeartQuest centrifugal blood pump (CF4b, MedQuest Products)
Comparison
Multiobjective hemodynamic control algorithm… vs Controllers relying on individual indices
Design
Preclinical
Authors
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In vitro VAD control algorithm requires in vivo validation before clinical use; leaves open translation of perfusion-collapse trade-off.
A novel multiobjective control algorithm for ventricular assist devices showed improved robustness in an in vitro mock circulatory loop compared to single-index controllers.
Gwak et al. (2005) studied end-stage heart failure. Multiobjective hemodynamic control algorithm vs. controllers relying on individual indices was evaluated on responsiveness of the controller to change in preload and afterload. A multiobjective hemodynamic control algorithm demonstrated more robust performance in an in vitro mock circulatory simulator compared with controllers relying on individual indices.
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