In ICU patients with chronic systolic heart failure, each quartile increase in serum albumin level was associated with a 35% reduction in 90-day all-cause mortality (HR 0.65).
Cohort (n=7,121)
No
Does serum albumin level predict short-term mortality in patients with chronic systolic heart failure in the ICU?
Serum albumin levels are an independent predictor of short-term (14-, 28-, and 90-day) all-cause mortality in ICU patients with chronic systolic heart failure.
Hazard Ratio: 0.65 (95% CI 0.61–0.7)
p-value: p=<0.0001
Abstract Decreased albumin levels are common in chronic heart failure (HF), but little is known about its role in mortality risk in HF. This study developed a cohort prediction model based on 7,121 individuals with heart failure to evaluate the short-term mortality and prognostic role of albumin in patients with chronic HF. The cohort was from intensive care unit between 2001 to 2012 in a publicly available clinical database in intensive care called MIMIC III. We used a generalized additive model to determine the nonlinear correlation between serum uric acid and 14th - day, 28th - day and 90th day all-cause mortality in patients with heart failure. The results showed that serum albumin was an independent risk factor for 14th -,28th - and 90th day all-cause mortality, and had a linear relationship with all-cause mortality in Chronic systolic heart failure. There is an interaction between ARDS and the influence of albumin on the outcome. The all-cause mortality on the 90th day predicted better clinical results with the all-cause mortality on the 14th day.
Chao et al. (Mon,) conducted a cohort in Chronic systolic heart failure (n=7,121). Serum albumin level vs. Lower serum albumin levels was evaluated on 90-day all-cause mortality (per quartile increase in serum albumin) (HR 0.65, 95% CI 0.61-0.70, p=<0.0001). In ICU patients with chronic systolic heart failure, each quartile increase in serum albumin level was associated with a 35% reduction in 90-day all-cause mortality (HR 0.65).