Key result
In ICU patients with chronic systolic heart failure, each quartile increase in serum albumin level was associated with a 35% reduction in 90-day all-cause mortality (HR 0.65).
Why the study?
Decreased albumin levels are common in chronic heart failure, but little is known about its role in mortality risk in HF.
Does serum albumin level predict short-term mortality in patients with chronic systolic heart failure in the ICU?
Cohort (n=7,121)
No
Does serum albumin level predict short-term mortality in patients with chronic systolic heart failure in the ICU?
Serum albumin levels are an independent predictor of short-term (14-, 28-, and 90-day) all-cause mortality in ICU patients with chronic systolic heart failure.
May aid short-term mortality prediction in ICU HF patients; hypothesis-generating and requires prospective validation.
Decreased albumin levels are common in chronic heart failure (HF), but little is known about its role in mortality risk in HF. This study developed a cohort prediction model based on 7,121 individuals with heart failure to evaluate the short-term mortality and prognostic role of albumin in patients with chronic HF. The cohort was from intensive care unit between 2001 to 2012 in a publicly available clinical database in intensive care called MIMIC III. We used a generalized additive model to determine the nonlinear correlation between serum uric acid and 14th - day, 28th - day and 90th day all-cause mortality in patients with heart failure. The results showed that serum albumin was an independent risk factor for 14th -,28th - and 90th day all-cause mortality, and had a linear relationship with all-cause mortality in Chronic systolic heart failure. There is an interaction between ARDS and the influence of albumin on the outcome. The all-cause mortality on the 90th day predicted better clinical results with the all-cause mortality on the 14th day.
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Chao et al. (2022) conducted a cohort in Chronic systolic heart failure (n=7,121). Serum albumin level vs. Lower serum albumin levels was evaluated on 90-day all-cause mortality (per quartile increase in serum albumin) (HR 0.65, 95% CI 0.61-0.70, p=<0.0001). In ICU patients with chronic systolic heart failure, each quartile increase in serum albumin level was associated with a 35% reduction in 90-day all-cause mortality (HR 0.65).
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