Key result
Inhibition of the SR Ca2+ pump by cyclopiazonic acid dose-dependently suppressed spontaneous sinoatrial node cell firing up to ≈50%, proportionally shifting the LCR period and cycle length (R2=0.98).
Population
Rabbit sinoatrial node cells (SANCs)
Design
Preclinical
Authors
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Links SR calcium replenishment to pacemaker firing in rabbits; leaves open human sinoatrial node relevance.
The spontaneous beating rate of sinoatrial node cells is critically determined by the rate of sarcoplasmic reticulum Ca2+ replenishment, which regulates the timing of local Ca2+ releases.
Vinogradova et al. (2010) studied Sinoatrial node pacemaker cells. Cyclopiazonic acid and modulators of phospholamban phosphorylation was evaluated on LCR period and spontaneous cycle length. Inhibition of the SR Ca2+ pump by cyclopiazonic acid dose-dependently suppressed spontaneous sinoatrial node cell firing up to ≈50%, proportionally shifting the LCR period and cycle length (R2=0.98).
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