Key result
Sarcolipin mRNA is expressed specifically in the atria, increases during development, and is down-regulated during hypertrophic remodeling, suggesting it is an atrial-specific regulator of Ca2+ cycling.
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No practice change warranted; leaves open sarcolipin as atrial calcium target for future human studies.
Minamisawa et al. (2003) studied Hypertrophic remodeling. Hypertrophic remodeling and development was evaluated on Sarcolipin mRNA expression. Sarcolipin mRNA is expressed specifically in the atria, increases during development, and is down-regulated during hypertrophic remodeling, suggesting it is an atrial-specific regulator of Ca2+ cycling.
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