Key result
In dogs, chronic complete atrioventricular block leads to biventricular myocyte hypertrophy and cellular electrophysiological remodeling that predisposes to torsade de pointes.
Chronic AVB in dogs leads to biventricular myocyte hypertrophy and cellular electrophysiological remodeling that predisposes to class III-dependent Torsade de Pointes.
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May inform mechanisms in canine AVB models; leaves open translation to human TdP risk.
Volders et al. (1998) studied Chronic complete atrioventricular block. Chronic complete atrioventricular block vs. Sinus rhythm was evaluated on Myocyte size, action potential duration, and incidence of early afterdepolarizations. In dogs, chronic complete atrioventricular block leads to biventricular myocyte hypertrophy and cellular electrophysiological remodeling that predisposes to torsade de pointes.
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