Chronic AV block in dogs induces electrophysiological and anatomical remodeling that significantly enhances susceptibility to drug-induced QT prolongation and torsade de pointes.
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Chronic AV block heightens cisapride-induced TdP in dogs; supports remodeled models for proarrhythmia screening but leaves human translation open.
Sugiyama et al. (2002) studied this question.
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