Key result
Complete metabolic inhibition in guinea-pig ventricular myocytes decreased the Ca2+ transient primarily by depressing the Ca2+ current rather than depleting intracellular Ca2+ stores.
Population
patch-clamped guinea-pig ventricular myocytes, loaded via the patch pipette with the Ca2+ indicator Fura-2
Comparison
carbonyl cyanide-p-trifluoromethoxyphenylhydrazon… vs control conditions
Design
Preclinical
Authors
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Metabolic inhibition impairs triggered Ca²⁺ release in myocytes; leaves open its role in ischemic contractile failure.
During severe metabolic inhibition in guinea-pig ventricular myocytes, the reduction in the intracellular calcium transient is primarily due to depression of the calcium current rather than depletion of intracellular calcium stores.
Goldhaber et al. (1991) studied this question. Complete metabolic inhibition (FCCP and 2-deoxyglucose) vs. Control conditions was evaluated on Excitation-contraction coupling (Ca2+ current and [Ca2+]i transient). Complete metabolic inhibition in guinea-pig ventricular myocytes decreased the Ca2+ transient primarily by depressing the Ca2+ current rather than depleting intracellular Ca2+ stores.
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