Population
Single, enzymatically isolated guinea pig ventricular myocytes
Comparison
3-min periods of anoxia with glucose-free Tyrode… vs Control periods, hypoxia, and metabolic inhibition
Design
Preclinical
Authors
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May guide mechanistic studies of anoxic myocyte injury; leaves open clinical translation pending in vivo validation.
Anoxia reversibly decreases the amplitude and slows the kinetics of intracellular Ca2+ transients in isolated guinea pig ventricular myocytes.
Seki et al. (1995) studied this question.
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