Population
Isolated ventricular heart cells of the guinea-pig
Comparison
Anoxia (PO2 < 0.1 Torr) vs Reoxygenation / baseline normoxia
Design
Preclinical
Authors
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Supports KATP mediation of anoxic K+ current in guinea-pig myocytes; leaves open translation to human ischemia.
Anoxia induces a time-independent K+ current in guinea-pig ventricular cells exclusively through the opening of KATP channels due to decreased submembrane ATP levels.
Benndorf et al. (1992) studied this question.
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