Key result
During hypoxia and ischemia, activation of a very small fraction (0.41%) of maximal ATP-sensitive K+ channel current is sufficient to double systolic K+ efflux and shorten action potential duration.
Activation of a very small fraction (0.41%) of maximal ATP-sensitive K+ channel current is sufficient to account for the observed K+ efflux and action potential shortening during early myocardial hypoxia and ischemia.
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Questions KATP role in early ischaemia despite high ATP; leaves open ionic mechanisms of APD shortening.
Weiss et al. (1992) studied Myocardial ischaemia and hypoxia. Hypoxia and ischaemia vs. Control conditions was evaluated on K+ efflux rates and action potential duration (APD) shortening. During hypoxia and ischemia, activation of a very small fraction (0.41%) of maximal ATP-sensitive K+ channel current is sufficient to double systolic K+ efflux and shorten action potential duration.
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