August 1, 1996Circulation Research

Simulation of Action Potentials From Metabolically Impaired Cardiac Myocytes

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Population

Computer model of cardiac ventricular myocytes (Luo-Rudy ionic model)

Design

Preclinical

Authors

JFJ.M. FerreroUniversitat Politècnica de València JSJavier SáizUniversitat Politècnica de València JFJ.M. FerreroUniversitat Politècnica de València

Discussion

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Implication

IK-ATP activation insufficiently explains ischemic K+ efflux; leaves open other mechanisms in hypoxia models.

Structured PICO

Population

Computer model of cardiac ventricular myocytes (Luo-Rudy ionic model)

Intervention

Simulation of different degrees of activation of ATP-sensitive K+ current (IK-ATP)

Outcome

Action potential duration and K+ effluxsurrogate

Computer modeling suggests that while a very small fraction of open KATP channels significantly shortens action potential duration during ischemia, other mechanisms must contribute to the observed K+ efflux.

Cite This Study

Ferrero et al. (1996) studied this question.

synapsesocial.com/papers/6a896613abb0ef83c5c97f58 https://doi.org/10.1161/01.res.79.2.208

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Simulation of Action Potentials From Metabolically Impaired Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Simulation of Action Potentials From Metabolically Impaired Cardiac Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider