December 1, 1990The Journal of PhysiologyOpen Access

Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.

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Population

Isolated sheep cardiac Purkinje fibre and guinea-pig papillary muscle subjected to simulated ischaemia

Comparison

Sulphonylurea compounds vs Untreated simulated ischaemia

Design

Preclinical

Authors

RGR. GasserMedical University of Graz RVRichard D. Vaughan‐JonesElectrophysiology

Discussion

Member takes

Implication

Hypothesis-generating for KATP-mediated cardioprotection; leaves clinical translation untested.

Structured PICO

Population

Isolated sheep cardiac Purkinje fibre and guinea-pig papillary muscle subjected to simulated ischaemia (immersed in paraffin oil)

Intervention

Sulphonylurea compounds (glibenclamide 200 microM or tolbutamide 1 mM)

Comparator

Untreated simulated ischaemia

Outcome

Potassium (Ks+) efflux and action potential (AP) shorteningsurrogate

Inhibition of KATP channels with sulphonylureas prevents potassium efflux and action potential shortening during simulated myocardial ischemia in isolated mammalian cardiac muscle.

Cite This Study

Gasser et al. (1990) studied this question.

synapsesocial.com/papers/6a70bd255d37378ac1dde18b https://doi.org/10.1113/jphysiol.1990.sp018356

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Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider