Why the study?
Does pretreatment with ATP-sensitive K+ channel blockers prevent action potential shortening in hypoxic and ischaemic myocardium?
Population
Guinea-pig and canine isolated myocardium (ventricular myocytes and papillary muscles)
Comparison
ATP-sensitive K+ channel blockers vs No pretreatment
Design
Preclinical
Authors
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Other currents likely contribute to ischaemic action potential shortening beyond KATP channels; hypothesis-generating in animals and leaves clinical translation open.
Does pretreatment with ATP-sensitive K+ channel blockers prevent action potential shortening in hypoxic and ischaemic myocardium?
The study demonstrates that ATP-sensitive K+ channel activation only partially accounts for action potential shortening during myocardial hypoxia and ischaemia, suggesting other currents are also involved.
Nakaya et al. (1991) studied this question.
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