June 1, 1997AJP Heart and Circulatory Physiology

Cytosolic Ca2+, Na+, and pH in guinea pig ventricular myocytes exposed to anoxia and reoxygenation

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Population

Guinea pig ventricular myocytes

Design

Preclinical

Authors

LRL. RalenkotterUniversity of Kentucky CDC. DalesUniversity of Kentucky TDTavner J. DelcampJohnson & Johnson (United States)

Discussion

Member takes

Implication

Reoxygenation-induced acidification may partially protect myocytes from hypercontracture; extends cellular mechanisms but leaves open translation to clinical reperfusion injury.

Structured PICO

Population

Guinea pig ventricular myocytes

Intervention

Anoxia and glucose deprivation followed by oxygen and glucose restoration 15-30 min after the onset of rigor

Outcome

Cytosolic [Ca2+], [Na+], and pHsurrogate

In guinea pig ventricular myocytes, reoxygenation-induced secondary acidification provides partial protection against hypercontracture associated with calcium transients.

Cite This Study

Ralenkotter et al. (1997) studied this question.

synapsesocial.com/papers/6a8fca712c8b3ffde3f37ef7 https://doi.org/10.1152/ajpheart.1997.272.6.h2679

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Implication

Reoxygenation-induced acidification may partially protect myocytes from hypercontracture; extends cellular mechanisms but leaves open translation to clinical reperfusion injury.

Cytosolic Ca2+, Na+, and pH in guinea pig ventricular myocytes exposed to anoxia and reoxygenation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cytosolic Ca2+, Na+, and pH in guinea pig ventricular myocytes exposed to anoxia and reoxygenation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider