Key result
Inhibitors of H+-Na+ exchange such as EIPA produced a significant restorative effect on the contractility of the reperfused guinea-pig heart with increased proton and decreased Na+ and Ca2+.
Population
Isolated guinea-pig hearts (Langendorff) and mitochondria
Design
Preclinical
Authors
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Hypothesis-generating for Na+/H+ exchange inhibition in reperfusion; should not yet change clinical practice.
Inhibition of H+-Na+ exchange restores contractility and reduces cytosolic Na+ and Ca2+ overload during ischemia/reperfusion in isolated guinea-pig hearts.
Hotta et al. (1998) studied Ischemia/reperfusion injury. Agents affecting cytosolic ion milieu (e.g., EIPA, omeprazole) was evaluated on Cytosolic ion and energy milieu changes and contractility. Inhibitors of H+-Na+ exchange such as EIPA produced a significant restorative effect on the contractility of the reperfused guinea-pig heart with increased proton and decreased Na+ and Ca2+.
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