Key result
Bilateral nephrectomy successfully reduced systolic blood pressure from a pre-operative range of 185-220 mmHg to 91-153 mmHg at three months in a patient with ESRD and refractory hypertension.
Why the study?
Patients with end-stage renal disease frequently develop hypertension resistant to medications and volume control, highlighting the need to raise clinician awareness of bilateral nephrectomy as rescue therapy.
Does bilateral nephrectomy improve blood pressure in patients with ESRD and refractory hypertension?
Case Report (n=1)
Does bilateral nephrectomy improve blood pressure in patients with ESRD and refractory hypertension?
Bilateral nephrectomy may serve as an effective rescue therapy for refractory hypertension in patients with end-stage renal disease on hemodialysis.
Bilateral nephrectomy may control refractory hypertension in ESRD; hypothesis-generating case report leaves open need for prospective trials.
It's not uncommon for patients with end-stage renal disease (ESRD) to develop hypertension that is resistant to antihypertensive medications and volume control, making it a challenge to control blood pressure in those patients. In this article, we present a 71-year-old female with a history of ESRD on intermittent hemodialysis (IHD), who developed refractory hypertension despite the use of seven antihypertensive agents in addition to IHD. The patient underwent bilateral nephrectomy as a last resort therapy for managing resistant hypertension, which led to a significant improvement in blood pressure (BP) and decreasing the number and doses of antihypertensive agents. This article aims to raise the awareness and alertness of clinicians to the efficacy of bilateral nephrectomy as rescue therapy for refractory hypertension in hemodialysis patients.
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Aldiabat et al. (2020) conducted a case report in Refractory hypertension in end-stage renal disease (n=1). Bilateral nephrectomy vs. Pre-operative state was evaluated on Blood pressure reduction. Bilateral nephrectomy successfully reduced systolic blood pressure from a pre-operative range of 185-220 mmHg to 91-153 mmHg at three months in a patient with ESRD and refractory hypertension.
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