Key result
Abnormal D-dimer levels one month after anticoagulant withdrawal significantly increased the risk of recurrent VTE compared to normal levels (HR 3.32; 95% CI 1.78-6.75; p<0.0001).
Why the study?
Do D-dimer levels and residual venous obstruction predict recurrent VTE in patients after anticoagulation withdrawal for a first idiopathic DVT?
Population
400 outpatients after oral anticoagulant therapy suspension for a first episode of idiopathic proximal deep…
Comparison
Abnormal D-dimer measured 30+/-10 days after OAT… vs Normal D-dimer measured 30+/-10 days after OAT…
Design
Cohort
Follow-up
2 years
Authors
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D-dimer testing one month post-withdrawal may stratify recurrence risk after idiopathic DVT; leaves open whether results should guide extended anticoagulation.
Cohort (n=400)
Do D-dimer levels and residual venous obstruction predict recurrent VTE in patients after anticoagulation withdrawal for a first idiopathic DVT?
Hazard Ratio: 3.32 (95% CI 1.78–6.75)
p-value: p=<0.0001
Abnormal D-dimer at one month after anticoagulation withdrawal is an independent risk factor for recurrent VTE, whereas residual venous obstruction does not influence recurrence risk.
Legnani et al. (2005) conducted a cohort in First episode of idiopathic proximal deep vein thrombosis (n=400). Abnormal D-dimer levels vs. Normal D-dimer levels was evaluated on Recurrent venous thromboembolism (VTE) (HR 3.32, 95% CI 1.78-6.75, p=<0.0001). Abnormal D-dimer levels one month after anticoagulant withdrawal significantly increased the risk of recurrent VTE compared to normal levels (HR 3.32; 95% CI 1.78-6.75; p<0.0001).
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