Key result
In an animal model of congestive heart failure, approximately 21% of CHF myocytes demonstrated spontaneous Ca(2+) waves compared with very little of this activity in control rats.
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Animal findings on Ca²⁺ defects in rat HF do not inform care; leaves open human mechanistic relevance.
Wasserstrom et al. (2009) studied Congestive heart failure. Congestive heart failure (spontaneously hypertensive rats) vs. Wistar-Kyoto control rats was evaluated on Spontaneous Ca(2+) waves. In an animal model of congestive heart failure, approximately 21% of CHF myocytes demonstrated spontaneous Ca(2+) waves compared with very little of this activity in control rats.
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