Key result
Compared to stable normotension, remaining at stage 1 hypertension was associated with an 80% higher risk of incident cardiovascular disease (HR 1.80).
Why the study?
Hypertension is the leading cause of CVD and mortality, but the impact of 3-year changes across 2017 ACC/AHA BP categories on incident CVD needed assessment.
Does change in blood pressure status over 3 years affect the risk of incident cardiovascular disease in adults without prevalent CVD?
Population
3,685 Tehranians aged ≥30 years free of prevalent CVD with BP <140/90 mmHg not on BP-lowering medications
Comparison
Changes in 3 years across BP categories vs stable normotension
Design
Cohort study
Follow-up
Median of 11.7 years
Authors
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Stage 1 HTN persistence or incidence signals higher CVD risk even after regression; leaves open whether targeting these thresholds alters outcomes.
Cohort (n=3,685)
Does change in blood pressure status over 3 years affect the risk of incident cardiovascular disease in adults without prevalent CVD?
Hazard Ratio: 1.8 (95% CI 1.29–2.52)
Prevalent and incident stage 1 hypertension, as defined by the 2017 ACC/AHA guidelines, are significantly associated with a higher risk of cardiovascular disease, supporting the need for antihypertensive management in these patients.
Kabootari et al. (2023) conducted a cohort in Hypertension (n=3,685). Remaining at stage 1 hypertension vs. Stable normotension was evaluated on Incident cardiovascular disease (HR 1.80, 95% CI 1.29-2.52). Compared to stable normotension, remaining at stage 1 hypertension was associated with an 80% higher risk of incident cardiovascular disease (HR 1.80).
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