Key result
Increased passive force depressed endothelium-dependent relaxation, with SHRSP aortae showing impaired relaxation and lesser influence by passive force compared to WKY rats.
Increased passive force depresses endothelium-dependent relaxation, an effect mediated by endothelium-derived contracting factor from the cyclo-oxygenase pathway, which is impaired in stroke-prone spontaneously hypertensive rats.
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No immediate clinical implications for hypertension; leaves open whether passive force modulates endothelial function in patients.
Sekiguchi et al. (1996) studied Hypertension (animal model). Passive force vs. WKY rats (normotensive control) was evaluated on Contraction and endothelium-dependent relaxation. Increased passive force depressed endothelium-dependent relaxation, with SHRSP aortae showing impaired relaxation and lesser influence by passive force compared to WKY rats.
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