Key result
Arterial smooth muscle from spontaneously hypertensive rats exhibits elevated uptake1 activity at an earlier age compared to venous or nonvascular smooth muscle.
Population
Spontaneously hypertensive rats, normotensive Wistar-Kyoto rats, and genetically related cross-bred strains…
Comparison
In vitro pretreatment of isolated smooth muscle… vs Tissues prior to cocaine treatment, and…
Design
Preclinical
Authors
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No clinical implications from this animal model; leaves open uptake1's role in human hypertension onset.
This preclinical study demonstrates that elevated neuronal uptake1 activity occurs selectively in arterial smooth muscle of spontaneously hypertensive rats prior to changes in nonarterial smooth muscle, correlating with blood pressure.
Laher et al. (1984) studied Hypertension. Spontaneously hypertensive rat (SHR) strain vs. Normotensive Wistar-Kyoto (WKY) rats was evaluated on Noradrenaline mean effective dose (ED50) and ED50 ratio before and after cocaine pretreatment. Arterial smooth muscle from spontaneously hypertensive rats exhibits elevated uptake1 activity at an earlier age compared to venous or nonvascular smooth muscle.
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