Key result
Four texture features of epicardial adipose tissue on PCCT showed significant differences between patients with and without coronary artery calcification.
Why the study?
Epicardial adipose tissue is suspected to be linked to coronary artery calcification, making improved diagnostic methods important, with radiomics and photon-counting CT offering a potential advance.
Do radiomic texture features of epicardial adipose tissue on PCCT correlate with the presence and severity of coronary artery calcification?
Observational (n=53)
No
Do radiomic texture features of epicardial adipose tissue on PCCT correlate with the presence and severity of coronary artery calcification?
Radiomic texture analysis of epicardial adipose tissue on novel photon-counting CT identifies specific features associated with coronary artery calcification, offering a potential new imaging biomarker for atherosclerosis.
Hypothesis-generating for PCCT radiomics in epicardial adipose tissue; prospective validation required before diagnostic use.
(1) Background: Epicardial adipose tissue influences cardiac biology in physiological and pathological terms. As it is suspected to be linked to coronary artery calcification, identifying improved methods of diagnostics for these patients is important. The use of radiomics and the new Photon-Counting computed tomography (PCCT) may offer a feasible step toward improved diagnostics in these patients. (2) Methods: In this retrospective single-centre study epicardial adipose tissue was segmented manually on axial unenhanced images. Patients were divided into three groups, depending on the severity of coronary artery calcification. Features were extracted using pyradiomics. Mean and standard deviation were calculated with the Pearson correlation coefficient for feature correlation. Random Forest classification was applied for feature selection and ANOVA was performed for group comparison. (3) Results: A total of 53 patients (32 male, 21 female, mean age 57, range from 21 to 80 years) were enrolled in this study and scanned on the novel PCCT. "Original_glrlm_LongRunEmphasis", "original_glrlm_RunVariance", "original_glszm_HighGrayLevelZoneEmphasis", and "original_glszm_SizeZoneNonUniformity" were found to show significant differences between patients with coronary artery calcification (Agatston score 1-99/≥100) and those without. (4) Conclusions: Four texture features of epicardial adipose tissue are associated with coronary artery calcification and may reflect inflammatory reactions of epicardial adipose tissue, offering a potential imaging biomarker for atherosclerosis detection.
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Mundt et al. (2024) conducted an observational in Coronary artery calcification (n=53). Epicardial adipose tissue texture features (radiomics) vs. Patients without coronary artery calcification was evaluated on Differences in epicardial adipose tissue texture features. Four texture features of epicardial adipose tissue on PCCT showed significant differences between patients with and without coronary artery calcification.
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