Key result
In hypokalaemic murine hearts, arrhythmic activity at long cycle lengths was associated with an increased critical angle between action potential duration and refractory period, an effect reversed by lidocaine.
Population
Langendorff-perfused murine hearts
Comparison
Lidocaine and pacing over a range of baseline… vs Normokalaemic (5.2 mM K) hearts and baseline…
Design
Preclinical
Authors
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Reproduces known effects in murine model; leaves open clinical translation pending in vivo validation.
p-value: p=<0.05
A novel graphical analysis of APD90 and VERP provides a sensitive indication of arrhythmogenicity and the antiarrhythmic effects of lidocaine in murine hearts.
Sabir et al. (2007) studied Arrhythmogenicity in hypokalaemia. Hypokalaemia and Lidocaine vs. Normokalaemia (5.2 mM K+) was evaluated on Arrhythmogenicity and APD90/VERP relationship (critical angle θ) (p=<0.05). In hypokalaemic murine hearts, arrhythmic activity at long cycle lengths was associated with an increased critical angle between action potential duration and refractory period, an effect reversed by lidocaine.
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