Key result
Hypokalaemia induced alternans and arrhythmia in murine hearts, associated with increased maximal gradients of restitution curves (from 0.55 to 2.35 in the epicardium, P<0.05), which were prevented by lidocaine.
Why the study?
Does lidocaine prevent alternans and arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts?
Does lidocaine prevent alternans and arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts?
Absolute Event Rate: 2.35% vs 0.55%
p-value: p=<0.05
Alternans contributes a dynamic component to the arrhythmic substrate during hypokalaemia, which can be abolished by lidocaine through modulation of restitution.
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Lidocaine may suppress hypokalaemia-induced alternans; hypothesis-generating for clinical translation.
Sabir et al. (2007) studied Hypokalaemia-induced arrhythmogenicity. Hypokalaemia and Lidocaine vs. Normokalaemia (5.2 mM K+) was evaluated on Maximal gradients of restitution curves in the epicardium (p=<0.05). Hypokalaemia induced alternans and arrhythmia in murine hearts, associated with increased maximal gradients of restitution curves (from 0.55 to 2.35 in the epicardium, P<0.05), which were prevented by lidocaine.
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