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April 1, 1998American Journal of Hypertension

Microalbuminuria Is an Early Marker of Target Organ Damage in Essential Hypertension

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Key result

Microalbuminuria in essential hypertension was associated with greater left ventricular mass index (167 vs 139 g/m2, P<0.001) and increased carotid wall thickness (12.5 vs 11.7 mm, P<0.001).

Why the study?

Is microalbuminuria associated with early target organ damage in patients with essential hypertension?

Population

53 subjects, including 33 patients with essential hypertension and 20 healthy normotensive controls, matched…

Comparison

Presence of microalbuminuria vs Absence of microalbuminuria and healthy…

Design

Cross-sectional

Authors

RPRoberto PontremoliUniversity of Foggia

Discussion

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Implication

Microalbuminuria may mark early target organ damage in hypertension; leaves open whether screening or intervention improves outcomes.

Study Design

Type

Observational (n=53)

Structured PICO

Is microalbuminuria associated with early target organ damage in patients with essential hypertension?

P
Population
53 subjects including 33 with essential hypertension (17 with and 16 without microalbuminuria) and 20 healthy normotensive controls, matched for age, gender, and BMI.
E
Exposure
Presence of microalbuminuria
C
Comparator
Absence of microalbuminuria (normoalbuminuric hypertensive patients) and healthy normotensive controls
O
Outcome
Early target organ damage (left ventricular mass index, carotid wall thickness, and renal vascular impedance)surrogate

Main Result

Absolute Event Rate: 167% vs 139%

p-value: p=<0.001

Microalbuminuria in essential hypertension serves as an early marker of diffuse target organ damage, including increased left ventricular mass, carotid wall thickness, and renal vascular resistance.

Cite This Study

Roberto Pontremoli (1998) conducted an observational in Essential hypertension (n=53). Microalbuminuria vs. Normoalbuminuria and healthy normotensive subjects was evaluated on Left ventricular mass index (LVMI) (p=<0.001). Microalbuminuria in essential hypertension was associated with greater left ventricular mass index (167 vs 139 g/m2, P<0.001) and increased carotid wall thickness (12.5 vs 11.7 mm, P<0.001).

synapsesocial.com/papers/6a6a5ff626cff2e2f6f405b9https://doi.org/10.1016/s0895-7061(97)00498-6

Topics

Hypertension managementEchocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence and Clinical Correlates of Microalbuminuria in Essential Hypertension1997 · 215 citations
  2. 2Prevalence of micro- and macroalbuminuria and their relationship with other cardiovascular risk factors in essential hypertension1995 · 38 citations
  3. 3Prevalence of Microalbuminuria in a Large Population of Patients with Mild to Moderate Essential Hypertension2008 · 164 citations
  4. 4Renal haemodynamics and organ damage in young hypertensive patients with different plasma renin activities after ACE inhibition1992 · 19 citations
  5. 5Plasma Prorenin Activity and Complications in Children with Insulin-Dependent Diabetes Mellitus1990 · 141 citations