Key result
Increased systolic blood pressure variability (highest vs lowest quintile) in the first 72 hours of acute stroke was associated with increased in-hospital mortality (OR 23.18; 95% CI 10.88-49.37).
Why the study?
The influence of short-term variations in blood pressure in acute stroke on clinical outcomes remains uncertain.
Does increased blood pressure variability in the first 72 hours of acute stroke admission increase the risk of mortality?
Cohort (n=2,554)
No
Does increased blood pressure variability in the first 72 hours of acute stroke admission increase the risk of mortality?
Odds Ratio: 23.18 (95% CI 10.88–49.37)
p-value: p=<0.001
Higher short-term blood pressure variability in the first 72 hours of acute stroke admission is strongly associated with increased in-hospital and 1-year mortality.
Does not support targeting BP variability; hypothesis-generating and requires prospective confirmation before practice change.
OBJECTIVES: The influence of short-term variations in blood pressure (BP) in acute stroke on clinical outcomes remains uncertain. Our study explores the relationship between BP variability (BPV) from stroke admission up to 72 hours and in-hospital and 1-year mortality. DESIGN: Retrospective observational cohort study. SETTING: Hamad General Hospital (HGH) a tertiary care stroke centre in Qatar. PARTICIPANTS: 2820 participants were initially included. After the exclusion of ineligible subjects, 2554 patients (82.5% male, median age 53±9 years) were included. 893 (34.96%) were from the Middle East and North Africa, 1302 (50.98%) were from South Asia, 258 (10.10%) from Southeast Asia, 9 (0.35%) were from East Asia and 92 (3.60%) were from other regions. Eligible participants were adult patients above 18 years of age who presented with acute ischaemic or haemorrhagic stroke. Excluded individuals were those younger than 18 years, had incomplete data, had transient ischaemic attack (TIA), had severe hypoglycaemia on admission (<3.3 mmol/L) or had a history of chronic kidney disease (CKD). INTERVENTIONS: We measured the BP every 4 hours over 3 days with a total of 18 readings from stroke admission. We then categorised BPV into five (L1-L5) and four (L1-L4) levels for systolic and diastolic BPs, respectively, and evaluated their association with mortality. RESULTS: There were increased odds of in-hospital mortality with increased systolic and diastolic variability (L2, OR 2.64, 95% CI 1.44 to 4.84; L3, OR 4.20 95% CI 2.14 to 8.24; L4, OR 10.14, 95% CI 4.93 to 20.85; L5, OR 23.18, 95%CI 10.88 to 49.37), (p=0.002 to <0.001) and (L2, OR 1.61, 95% CI 0.96 to 2.69; L3, OR 2.95, 95% CI 1.70 to 5.12 and L4, OR 8.00, 95% CI 4.49 to 14.25), (p=0.071 to <0.001), respectively. This was consistent with 1-year mortality for systolic and diastolic BPs. CONCLUSION: In a retrospective cohort of ethnically diverse acute stroke patient population, BPV was significantly associated with both in-hospital and 1-year mortality. Further prospective research is needed to define BPV and establish interventions and management accordingly.
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Tawengi et al. (2025) conducted a cohort in Acute ischaemic or haemorrhagic stroke (n=2,554). High blood pressure variability (BPV) within 72 hours of admission vs. Low blood pressure variability was evaluated on In-hospital mortality (highest vs lowest quintile of systolic BPV) (OR 23.18, 95% CI 10.88-49.37, p=<0.001). Increased systolic blood pressure variability (highest vs lowest quintile) in the first 72 hours of acute stroke was associated with increased in-hospital mortality (OR 23.18; 95% CI 10.88-49.37).
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