Key result
Left hemisphere acute ischemic stroke was associated with a higher rate of normal heart rate turbulence parameters compared to right hemisphere stroke (41.9% vs 24.3%).
Why the study?
Acute ischemic stroke induces adverse cardiovascular effects by affecting the autonomic nervous system, but whether HRV and HRT differ compared to controls or between right and left hemisphere strokes required evaluation.
Does acute ischemic stroke and its hemisphere localization affect autonomic nervous function as measured by HRV and HRT?
Observational (n=228)
Does acute ischemic stroke and its hemisphere localization affect autonomic nervous function as measured by HRV and HRT?
Absolute Event Rate: 41.9% vs 24.3%
p-value: p=<0.001
Acute ischemic stroke affects autonomic nervous function, with right hemisphere strokes showing greater impairment in heart rate turbulence than left hemisphere strokes.
Right-hemisphere stroke may link to greater autonomic impairment; hypothesis-generating and requires prospective validation before any clinical use.
BACKGROUND: Acute ischemic stroke (AIS) induces adverse effects on the cardiovascular system by affecting the autonomic nervous system (ANS). OBJECTIVES: This study aimed to determine whether the parameters of heart rate variability (HRV) and heart rate turbulence (HRT) differed in patients with AIS as compared to that in the control group. Furthermore, we aimed to determine the differences in the involvement of the ANS between right and left hemisphere (LH) strokes. METHODS: A total of 148 [74 right hemispheres (RH) and 74 left hemispheres] patients with AIS and 80 control subjects were included in the study. The Holter device was used to obtain elcctrocardiogram readings for over 20 h from all patients. Results of HRV and HRT parameters [Tonset (TO) and Tslope (TS)] were acquired through an automatic analysis of the program. RESULTS: = <0.001). HRV parameters were detected to be similar in patients, irrespective of the left or right infarct. TO and TS were normal in 31 patients (41.9%) with left hemisphere localization and in only 18 patients (24.3%) with right hemisphere localization. CONCLUSIONS: Combined evaluation of HRV and HRT parameters may provide important information regarding the alterations in the ANS in patients with AIS. The utility of HRT in the determination of ANS alterations in patients with AIS should be investigated in larger future prospective studies.
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Candemir et al. (2020) conducted an observational in Acute ischemic stroke (n=228). Left hemisphere vs right hemisphere acute ischemic stroke vs. Right hemisphere stroke / Control subjects was evaluated on Normal heart rate turbulence parameters (Tonset and Tslope) (p=<0.001). Left hemisphere acute ischemic stroke was associated with a higher rate of normal heart rate turbulence parameters compared to right hemisphere stroke (41.9% vs 24.3%).
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