Key result
High lifetime predicted ASCVD risk was associated with significantly increased odds of coronary artery calcium >0 in South Asian men (OR 1.97; 95% CI 1.2-3.2) and women (OR 3.14; 95% CI 1.5-6.6).
Why the study?
Do contemporary 10-year and lifetime predicted ASCVD risk algorithms accurately identify subclinical atherosclerosis burden in US South Asians?
Population
893 South Asians in the US, aged 40 to 79 years, free of atherosclerotic cardiovascular disease.
Comparison
High 10-year predicted ASCVD risk or high… vs Low 10-year predicted ASCVD risk or low lifetime…
Design
Cross-sectional
Authors
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Highlights potential ASCVD risk underestimation in US South Asians; leaves open need for ancestry-specific models and prospective validation.
Cross-Sectional (n=893)
Do contemporary 10-year and lifetime predicted ASCVD risk algorithms accurately identify subclinical atherosclerosis burden in US South Asians?
Effect estimate: OR 1.97 (men), OR 3.14 (women) (95% CI 1.2-3.2 (men), 1.5-6.6 (women))
Contemporary ASCVD risk assessment algorithms derived from non-Hispanic white and African-American samples can successfully identify substantial differences in atherosclerotic burden in US South Asians.
Kandula et al. (2014) conducted a cross-sectional in Subclinical atherosclerosis (n=893). High lifetime predicted ASCVD risk vs. Low lifetime predicted ASCVD risk was evaluated on Coronary artery calcium (CAC) higher than 0 (OR 1.97 (men), OR 3.14 (women), 95% CI 1.2-3.2 (men), 1.5-6.6 (women)). High lifetime predicted ASCVD risk was associated with significantly increased odds of coronary artery calcium >0 in South Asian men (OR 1.97; 95% CI 1.2-3.2) and women (OR 3.14; 95% CI 1.5-6.6).
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