Key result
Statin use was associated with significantly lower brachial-ankle pulse wave velocity compared to non-use in normotensive CAD patients (1331.68 vs 1468.61 cm/s, P=0.002), but not in hypertensive ones.
Why the study?
Does statin therapy improve arterial stiffness in normotensive and hypertensive patients with coronary artery disease?
Observational (n=437)
Does statin therapy improve arterial stiffness in normotensive and hypertensive patients with coronary artery disease?
Absolute Event Rate: 1331.68% vs 1468.61%
p-value: p=0.002
Statin therapy is associated with reduced arterial stiffness in normotensive patients with CAD, but this benefit appears to be blunted by concurrent hypertension.
Hypothesis-generating for hypertension-blunted statin effects on arterial stiffness in CAD; should not change practice without prospective trials.
BACKGROUND: Statins improve arterial stiffness in patients with coronary artery disease (CAD). Hypertension is a predominant contributor of arterial stiffening. However, the influence of hypertension on the effect of statins for improving arterial stiffness in CAD patients has seldom been investigated. Therefore, in this study, we investigated the relationships between statin use and arterial stiffness in normotensive and hypertensive CAD patients. METHODS: Brachial-ankle pulse wave velocity (ba-PWV) was measured in 437 patients, including 220 hypertensive CAD patients (121 used statins, 99 did not) and 217 normotensive CAD patients (105 used statins, 112 did not). The normotensive and hypertensive CAD patients were matched according to age, sex, and body mass index (BMI). RESULTS: In the normotensive and hypertensive CAD patients, lipid profiles were significantly improved in the statin group compared with the non-statin group. No significant differences in the administered statins (i.e., atorvastatin, simvastatin, rosuvastatin, and pravastatin) and statin therapy duration were found between normotensive and hypertensive CAD patients (all P > 0.05). No significant correlation of ba-PWV and statin therapy duration was found in all CAD patients, normotensive CAD patients, or hypertensive CAD patients (all P > 0.05). ba-PWV in the statin group was significantly lower than that in the non-statin group in normotensive CAD patients ((1331.68 ± 167.52) cm/s vs. (1468.61 ± 244.54) cm/s, P = 0.002) but not in hypertensive CAD patients (P > 0.05). In multiple linear regression analyses, statin therapy was significantly associated with ba-PWV after adjusting for confounding variables in normotensive CAD patients (P = 0.018) but not in hypertensive CAD patients (P > 0.05). CONCLUSIONS: Statins may significantly improve arterial stiffness in CAD patients, and hypertension may probably influence the effectiveness of statin therapy in improving arterial stiffness in this population. Further studies are required to investigate the effect of statins on arterial stiffness in normotensive and hypertensive CAD patients.
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Wang et al. (2013) conducted an observational in Coronary artery disease (n=437). Statin use vs. No statin use was evaluated on Brachial-ankle pulse wave velocity (ba-PWV) (p=0.002). Statin use was associated with significantly lower brachial-ankle pulse wave velocity compared to non-use in normotensive CAD patients (1331.68 vs 1468.61 cm/s, P=0.002), but not in hypertensive ones.
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