Key result
Higher platelet counts were significantly associated with an increased risk of thrombosis in adult cancer patients (OR 1.50; 95% CI 1.19-1.88).
Why the study?
Cancer-associated thrombosis is a major cause of morbidity and mortality, but while platelet count has been investigated as a predictor, knowledge regarding platelet activation parameters is sparse.
Do higher platelet counts and platelet activation parameters predict arterial and venous thrombosis in adult cancer patients?
Population
Adult cancer patients across 100 included studies
Comparison
Associations of platelet count, platelet indices, and platelet function/activation markers with thrombosis
Design
Systematic review and meta-analysis
Authors
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May support risk stratification in cancer-associated thrombosis; leaves open prospective validation before clinical adoption.
Meta-Analysis
Do higher platelet counts and platelet activation parameters predict arterial and venous thrombosis in adult cancer patients?
Odds Ratio: 1.5 (95% CI 1.19–1.88)
Higher platelet counts are significantly associated with an increased risk of cancer-associated thrombosis, highlighting their potential utility in thrombosis risk assessment.
Malte et al. (2023) conducted a meta-analysis in Cancer-associated thrombosis. Higher platelet counts was evaluated on thrombosis (OR 1.50, 95% CI 1.19-1.88). Higher platelet counts were significantly associated with an increased risk of thrombosis in adult cancer patients (OR 1.50; 95% CI 1.19-1.88).
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