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December 30, 2019Seminars in Thrombosis and Hemostasis

The association between platelet count and bleeding was most pronounced at platelet counts ≤ 10 × 10^9/L (mainly in hematological malignancies), and reduced platelet function was significantly associated with bleeding risk.

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Why the study?

While cancer patients face an elevated bleeding risk and platelets play a key role, safe thresholds for prophylactic platelet transfusion are mainly described in hematological malignancies, with sparse knowledge in solid tumors.

Is platelet count or function associated with bleeding risk in adult cancer patients?

Population

52 studies of adult cancer patients with hematological malignancy (n = 31), solid tumors (n = 11), or both (n = 10)

Comparison

Platelet count (n = 40) or function (n = 12) and bleeding

Design

PRISMA-guided systematic review

Authors

JLJulie Brogaard LarsenJHJohanne Andersen HøjbjergAHAnne‐Mette Hvas

Discussion

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Member takes

Overview

Supports prophylactic transfusion thresholds in hematological malignancies; extends evidence to platelet function while leaving gaps for solid tumors.

Structured PICO

Is platelet count or function associated with bleeding risk in adult cancer patients?

P
Population
52 studies investigating adult cancer patients with hematological malignancy (n=31), solid tumors (n=11), or both (n=10).
I
Intervention
Platelet count and/or platelet function analysis
O
Outcome
Bleeding riskhard clinical

This systematic review supports current guidelines for prophylactic platelet transfusions at counts ≤ 10 × 10^9/L in hematological cancer patients, while highlighting a lack of evidence for solid tumors and the potential value of platelet function testing.

Limitations

  • Knowledge is sparse for patients with solid tumors
  • Platelet function analysis is sparsely investigated so far

Cite This Study

Larsen et al. (2019) studied this question.

synapsesocial.com/papers/6a85c97bee60e6e86dae6feahttps://doi.org/10.1055/s-0039-3402429
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Platelet Parameters as Biomarkers for Thrombosis Risk in Cancer: A Systematic Review and Meta-analysis2023 · 11 citations
  2. 2Bleeding Risk in Patients with Cancer2024 · 9 citations
  3. 3Investigating Therapeutic Potential of Targeting Platelets in Cancer Treatment: A Literature Review2024 · 1 citations
  4. 4Risk and adverse clinical outcomes of thrombocytopenia among patients with solid tumors—a Danish population-based cohort study2024 · 4 citations
  5. 5Platelet function in malignant hematological disorders2015 · 11 citations