Population
Patients with malignant hematological disorders (e.g., leukemia)
Design
Review
Key result
Platelet counts between 6 and 80 × 10(9) platelets/l are a poor indicator of bleeding risk in malignant hematological disorders because they do not reflect functional activity.
Authors
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Questions utility of count-based transfusion thresholds in hematologic malignancy; leaves open validation of functional assays in prospective studies.
Platelet functional activity, rather than just absolute count, is crucial for assessing bleeding and thrombosis risk in malignant hematological disorders.
Moscardó et al. (2015) conducted a review in Malignant hematological disorders. Platelet function was evaluated. Platelet counts between 6 and 80 × 10(9) platelets/l are a poor indicator of bleeding risk in malignant hematological disorders because they do not reflect functional activity.
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