Key result
Animal models demonstrate that vaccines and antisera can protect against virus-induced type 1 diabetes when administered appropriately.
Highlights preclinical evidence that vaccination or antiserum administration can prevent virus-induced type 1 diabetes in susceptible animal models.
Mouse data on CVB vaccines do not inform T1D prevention; leaves open need for human studies.
Infectious agents, particularly Coxsackievirus B (CVB) group belonging to the Enterovirus genus of the family Picornaviridae, have been suggested to be the cause of virus-induced type 1 diabetes (T1D). Recently, Stone et al. showed that a CVB1 vaccine can protect CVB1-induced diabetes in suppressor of cytokine signaling 1 (SOCS1)-transgenic NOD mice [1]. It has been reported that inoculation of antiserum against diabetogenic D variant of murine encephalomyocarditis (EMC-D) virus prevented diabetes, only when transferred within 36 h after infection.
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Mine et al. (2018) conducted a review in Virus-induced type 1 diabetes (T1D). Animal models demonstrate that vaccines and antisera can protect against virus-induced type 1 diabetes when administered appropriately.
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