Why the study?
The study was designed to assess the influence of transit-time flow measurement in daily practice during coronary artery disease surgery.
Does inadequate graft flow (≤15 mL/minute) on the left anterior descending artery during CABG increase the risk of 30-day major adverse cardiac events?
Cohort (n=1,414)
Yes
Does inadequate graft flow (≤15 mL/minute) on the left anterior descending artery during CABG increase the risk of 30-day major adverse cardiac events?
Odds Ratio: 3.64 (95% CI 1.87–6.9)
p-value: p=<0.001
Routine intraoperative transit-time flow measurement during CABG identifies inadequate graft flow, which strongly predicts 30-day adverse cardiac events and should prompt surgical graft revision.
Objective The Evaluation of Transit-Time Flow in Coronary Artery Disease Surgery (EFCAD) registry aims to assess the influence of transit-time flow measurement (TTFM) in daily practice. Methods EFCAD is a prospective, multicenter study involving 9 centers performing TTFM during isolated coronary artery bypass grafting. Primary end point was occurrence and risk factors of major adverse cardiac events, including perioperative myocardial infarction, urgent postoperative coronary angiogram and/or revascularization, and hospital mortality. Secondary end points were rate of graft revision during surgery and factors affecting graft flow. We respected the limit values set by the experts: mean graft flow >15 mL/minute and pulsatility index ≤5. Results Between May 2017 and March 2021, 1616 patients were registered in the EFCAD database. After review, 1414 were included for analyses. Of those, 1176 were eligible for primary end point analysis. Graft revision, mainly due to inadequate TTFM values, occurred in 2% (29 patients). The primary end point occurred in 46 (3.9%) patients, and it was related with left anterior descending artery graft flow ≤15 mL/minute (odds ratio, 3.64; P < .001). Graft flow was related with number of grafts (3 vs 1-2, β = −1.6; 4-6 vs 1-2, β = −4.1; P < .001; β > 0 indicates higher flow), and graft origin (aorta vs Y, β = 9.2; in situ left internal thoracic artery vs Y, β = 3.2; in situ right internal thoracic artery vs Y, β = 2.3; P < .001). Conclusions Data from EFCAD study suggest that TTFM is reliable to evaluate graft flow, and acceptance of inadequate flow on left anterior descending artery anastomosis influence postoperative outcomes. In our opinion, TTFM assessment should be routinely used in coronary artery bypass procedures, even if interpretation depends on learning curves.
No takes yet. Share an insight, caveat, or question.
Laali et al. (2023) conducted a cohort in Coronary artery disease requiring isolated CABG (n=1,414). Inadequate (≤15 mL/minute) graft flow on the left anterior descending artery vs. Adequate (>15 mL/minute) graft flow was evaluated on Major adverse cardiac events (MACE) at 30 postoperative days (composite of perioperative myocardial infarction, urgent postoperative coronary angiogram/revascularization, and hospital mortality) (OR 3.64, 95% CI 1.87-6.90, p=<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: