Key result
In patients with atrial fibrillation, type 1 and type 2 diabetes increased mortality risk compared to no diabetes (HR 1.87; 95% CI 1.73-2.02 and HR 1.51; 95% CI 1.47-1.55, respectively).
Why the study?
To compare prognosis between individuals without diabetes, type 1 diabetes, and type 2 diabetes in atrial fibrillation, and to evaluate the significance of severe hypoglycaemia.
Does type 1 and type 2 diabetes mellitus increase the risk of mortality and cardiovascular events in patients with non-valvular atrial fibrillation?
Cohort (n=309,611)
Yes
Does type 1 and type 2 diabetes mellitus increase the risk of mortality and cardiovascular events in patients with non-valvular atrial fibrillation?
Hazard Ratio: 1.87 (95% CI 1.73–2.02)
In patients with atrial fibrillation, both type 1 and type 2 diabetes are associated with increased risks of mortality, cardiovascular events, and dementia, with type 1 diabetes conferring a higher risk than type 2.
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Diabetes associated with higher AF mortality; extends risk stratification data but leaves open need for targeted trials.
Karayiannides et al. (2022) conducted a cohort in non-valvular atrial fibrillation (n=309,611). Type 1 and type 2 diabetes mellitus vs. Individuals without diabetes was evaluated on all-cause mortality (HR 1.87, 95% CI 1.73-2.02). In patients with atrial fibrillation, type 1 and type 2 diabetes increased mortality risk compared to no diabetes (HR 1.87; 95% CI 1.73-2.02 and HR 1.51; 95% CI 1.47-1.55, respectively).
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