Key result
In 358 healthy Korean subjects, the CYP2C9*3 allele frequency was 0.060, and a novel allele, CYP2C9*13, was identified at a frequency of 0.006 (95% CI 0-0.012).
Why the study?
What are the allele and genotype frequencies of CYP2C9 in a healthy Korean population?
Cross-Sectional (n=358)
What are the allele and genotype frequencies of CYP2C9 in a healthy Korean population?
The study identifies a significantly higher frequency of the CYP2C9*3 allele in Koreans compared to other populations and reports a novel CYP2C9*13 allele.
Answers are grounded in this paper and cite their sources.
Korean CYP2C9 frequencies differ from other groups; leaves open ethnicity-specific dosing validation before clinical use.
AIMS: To determine the frequencies of the variant alleles and the genotypes of CYP2C9 in a Korean population. METHODS: Three hundred and fifty-eight healthy Korean subjects were studied. CYP2C9 alleles were detected by polymerase chain reaction-restriction fragment length polymorphism assays and direct sequencing assays. RESULTS: The allele frequencies were 0.934 for CYP2C9*1, 0.060 for CYP2C9*3 and 0.006 for CYP2C9*13. The CYP2C9*2,*4,*5 and *11 alleles were not detected. The frequencies of the CYP2C9*1/*1, *1/*3 and *1/*13 genotypes were 0.869, 0.120 and 0.011, respectively. CONCLUSION: The frequency of the CYP2C9*3 allele in the Korean population studied was significantly higher than reported elsewhere, and a novel allele, CYP2C9*13, was found at a frequency of 0.006 (95% confidence interval 0, 0.012). Only three genotypes of CYP2C9, CYP2C9*1/*1,*1/*3 and *1/*13 were observed in this Korean population.
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Bae et al. (2005) conducted a cross-sectional in Healthy (n=358). CYP2C9 allele and genotype frequencies was evaluated on CYP2C9 allele and genotype frequencies. In 358 healthy Korean subjects, the CYP2C9*3 allele frequency was 0.060, and a novel allele, CYP2C9*13, was identified at a frequency of 0.006 (95% CI 0-0.012).
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