August 4, 2003British Journal of Clinical PharmacologyOpen Access

Allele and genotype frequency of CYP2C19 in a Tamilian population

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Population

112 unrelated healthy human volunteers from a Tamilian population

Design

Cross-sectional

Authors

NGNathalie GérardInserm SVS. VasuSun Pharma (United States)JRJ. RosemaryPharmacoGenetics (China)

Discussion

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Implication

Distinct CYP2C19 distribution in Tamilians may affect clopidogrel response; leaves open population-specific pharmacogenetic validation.

Structured PICO

Population

112 unrelated healthy human volunteers from a Tamilian population

Outcome

Frequencies of CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles and CYP2C19 genotypessurrogate

The Tamilian population exhibits a distinct CYP2C19 allele distribution, including a higher frequency of the *1/*2 genotype and the presence of the *3 allele, which may impact the metabolism of drugs like clopidogrel.

Cite This Study

Gérard et al. (2003) studied this question.

synapsesocial.com/papers/6a7d79eae9ec6b5ffa6e4bf1 https://doi.org/10.1046/j.1365-2125.2003.01883.x

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Allele and genotype frequency of CYP2C19 in a Tamilian population

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Allele and genotype frequency of CYP2C19 in a Tamilian population

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider