Key result
Noradrenaline substantially suppressed the cholinergic effects of paraoxon in isolated rat atrial myocardium, indicating that cardiac non-quantal acetylcholine release is negatively regulated by noradrenaline.
Why the study?
Does noradrenaline regulate non-quantal release of acetylcholine in isolated rat atrial myocardium?
Population
Isolated rat right atrial preparations
Comparison
Noradrenaline in the presence of the… vs Baseline/paraoxon alone
Design
Preclinical
Authors
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Hypothesis-generating for cardiac cholinergic-adrenergic interactions; leaves open in vivo relevance and clinical translation.
Does noradrenaline regulate non-quantal release of acetylcholine in isolated rat atrial myocardium?
Cardiac non-quantal acetylcholine release can be negatively regulated by noradrenaline via alpha-adrenoceptors, demonstrating a novel mechanism of sympathetic-parasympathetic interaction in the heart.
Бородинова et al. (2013) studied Isolated rat right atrial preparations. Noradrenaline was evaluated on Cholinergic changes of electrical activity induced by paraoxon. Noradrenaline substantially suppressed the cholinergic effects of paraoxon in isolated rat atrial myocardium, indicating that cardiac non-quantal acetylcholine release is negatively regulated by noradrenaline.
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