Key result
Alterations in the cardiac milieu demonstrated that most atrial and ventricular intrinsic cardiac neurons generate concurrent stochastic activity predicated primarily upon cardiac chemotransduction.
Most atrial and ventricular intrinsic cardiac neurons generate concurrent stochastic activity predicated primarily upon cardiac chemotransduction, displaying relative independent short-term control over regional cardiac indexes.
Most intrinsic cardiac neurons integrate multimodal inputs; leaves open their reflex roles in conscious humans.
To quantify the concurrent transduction capabilities of spatially distributed intrinsic cardiac neurons, the activities generated by atrial vs. ventricular intrinsic cardiac neurons were recorded simultaneously in 12 anesthetized dogs at baseline and during alterations in the cardiac milieu. Few (3%) identified atrial and ventricular neurons (2 of 72 characterized neurons) responded solely to regional mechanical deformation, doing so in a tightly coupled fashion (cross-correlation coefficient r = 0.63). The remaining (97%) atrial and ventricular neurons transduced multimodal stimuli to display stochastic behavior. Specifically, ventricular chemosensory inputs modified these populations such that they generated no short-term coherence among their activities (cross-correlation coefficient r = 0.21 +/- 0.07). Regional ventricular ischemia activated most atrial and ventricular neurons in a noncoupled fashion. Nicotinic activation of atrial neurons enhanced ventricular neuronal activity. Acute decentralization of the intrinsic cardiac nervous system obtunded its neuron responsiveness to cardiac sensory stimuli. Most atrial and ventricular intrinsic cardiac neurons generate concurrent stochastic activity that is predicated primarily upon their cardiac chemotransduction. As a consequence, they display relative independent short-term (beat-to-beat) control over regional cardiac indexes. Over longer time scales, their functional interdependence is manifest as the result of interganglionic interconnections and descending inputs.
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Waldmann et al. (2006) studied this question. Alterations in the cardiac milieu (e.g., ventricular ischemia, chemosensory inputs) vs. Baseline was evaluated on Concurrent transduction capabilities (cross-correlation coefficient of neuronal activities). Alterations in the cardiac milieu demonstrated that most atrial and ventricular intrinsic cardiac neurons generate concurrent stochastic activity predicated primarily upon cardiac chemotransduction.
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