Key result
Trimethaphan injected into the SVC-Ao fat pad attenuated the negative inotropic, chronotropic, and dromotropic responses to cervical vagal stimulation by 33-37% in the dog heart.
Population
Anesthetized dogs with autonomically decentralized hearts
Design
Preclinical
Authors
Loading...
May identify novel autonomic targets in atrial disease; leaves open translation from canine SVC-Ao ganglia to humans.
Parasympathetic ganglionic cells in the SVC-Ao fat pad nonselectively control atrial contractile force, sinus cycle length, and AV conduction in the dog heart.
Tsuboi et al. (2000) studied Anesthetized dog (animal model). Trimethaphan or lidocaine injection into the SVC-Ao fat pad during vagal stimulation was evaluated on Right atrial contractile force, sinus cycle length (SCL), and atrioventricular (AV) conduction. Trimethaphan injected into the SVC-Ao fat pad attenuated the negative inotropic, chronotropic, and dromotropic responses to cervical vagal stimulation by 33-37% in the dog heart.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: